Brain painting is a non-invasive P300-based brain-computer interface (BCI) that allows painting without the use of muscular activity. The technology combines electroencephalography, signal processing algorithms and visual stimulation on a monitor to detect where the user focuses his attention, allowing him to voluntarily trigger commands to a painting software. The research project aims at assisting people afflicted with the Locked-in syndrome due to neurological or neuromuscular disease (e.g. amyotrophic lateral sclerosis ALS), who are severely restricted in communication with their environment, and therefore cut off from the possibility of creative expression.