Brendan Anthony O'Brien (born 2 September 1942) is a former Irish cricketer. O'Brien was a right-handed batsman. He was born at Galway in 1942. O'Brien made his first-class cricket debut for the Ireland cricket team in 1966 against Scotland. Between 1966 and 1981 he played 11 times for Ireland in first-class matches, the last of which also came against Scotland. He scored 319 runs at a batting average of 19.93, with a highest score of 45 not out. O'Brien also played for Ireland in two List A matches. He played domestically for Railway Union and South Leinster.