Brorphine
Brorphine is a piperidine-based opioid analgesic compound. Brorphine was originally discovered in a 2018 paper investigating functionally biased opioid compounds, with the intention of finding safer analgesics that produce less respiratory depression than typical opioids. Brorphine was originally reported to be highly biased, with an EC50 of 4.8nM for GTPγS binding and 182nM for β-arrestin recruitment, however a re-evaluation found no significant bias for any of the compounds tested, including brorphine. Its safety profile in any animal model has never been established. Despite the lack of safety information on the compound, brorphine has been sold as a designer drug since mid-2019, initially being identified in the US Midwest, though it has since been found in 2020 in Belgium. It is relat
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Brorphine
Brorphine is a piperidine-based opioid analgesic compound. Brorphine was originally discovered in a 2018 paper investigating functionally biased opioid compounds, with the intention of finding safer analgesics that produce less respiratory depression than typical opioids. Brorphine was originally reported to be highly biased, with an EC50 of 4.8nM for GTPγS binding and 182nM for β-arrestin recruitment, however a re-evaluation found no significant bias for any of the compounds tested, including brorphine. Its safety profile in any animal model has never been established. Despite the lack of safety information on the compound, brorphine has been sold as a designer drug since mid-2019, initially being identified in the US Midwest, though it has since been found in 2020 in Belgium. It is relat
has abstract
Brorphine is a piperidine-base ...... 100 cases as of October 2020.
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CAS number
2244737-98-0
ChEMBL
PubChem
Wikipage page ID
64,766,982
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1,026,155,344
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CAS number
ChEMBL
drug name
Brorphine
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IUPAC name
legal UK
PSA
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legal US
Schedule I
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PubChem
145,975,294
SMILES
CCN2CCCN3C4=CC=CC=C4NC3=O
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StdInChIKey
CNOFBGYRMCBVLO-UHFFFAOYSA-N
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comment
Brorphine is a piperidine-base ...... n 2020 in Belgium. It is relat
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label
Brorphine
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isPrimaryTopicOf
name
Brorphine
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