"Bust It Baby" is a single by American rapper Plies released on January 25, 2008. It is the first single from Plies' second album, Definition of Real. This was featured as a bonus track on his album, while "Bust It Baby Pt. 2" is the official track on the album. It features R&B-Pop singer Ne-Yo. The song features a noticeable sample of Janet Jackson's 1990 single "Come Back to Me", a #2 hit from her 1989 album "Janet Jackson's Rhythm Nation 1814". Janet is also featured on the song's official remix.