Butylphthalide
Butylphthalide (3-n-butylphthalide or NBP) is one of the chemical constituents in celery oil, along with sedanolide, which is primarily responsible for the aroma and taste of celery. Studies in animal models suggest that butylphthalide may be useful for the treatment of hypertension and may have neuroprotective effects. In 2002, NBP was approved in China for the treatment of cerebral ischemia. NBP undergoes extensive metabolism in humans. The major metabolites in human plasma were 3-OH-NBP, 10-OH-NBP, 10-CO-NBP, 11-COOH-NBP. The AUC of metabolites was much larger than that of NBP.
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Butylphthalide
Butylphthalide (3-n-butylphthalide or NBP) is one of the chemical constituents in celery oil, along with sedanolide, which is primarily responsible for the aroma and taste of celery. Studies in animal models suggest that butylphthalide may be useful for the treatment of hypertension and may have neuroprotective effects. In 2002, NBP was approved in China for the treatment of cerebral ischemia. NBP undergoes extensive metabolism in humans. The major metabolites in human plasma were 3-OH-NBP, 10-OH-NBP, 10-CO-NBP, 11-COOH-NBP. The AUC of metabolites was much larger than that of NBP.
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Butylphthalide (3-n-butylphtha ...... ted via sulfation of 3-OH-NBP.
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alternative name
3-Butylphthalide; 3-n-Butylphthalide
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IUPAC name
3-Butyl-2-benzofuran-1(3H)-one
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33,693,140
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1,020,965,195
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Butylphthalide (3-n-butylphtha ...... much larger than that of NBP.
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label
Butylphthalide
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