Cairanne (French pronunciation: ​[kɛʁan]; Occitan: Cairana) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France whose inhabitants were locally nicknamed leis afrontaires de Cairana, the cheeky ones from Cairanne. It dates from the mid-8th century and is located midway between Orange and Vaison-la-Romaine. The village economy depends largely on its production of wine that falls into the various categories of wines from the Rhône valley.