Caonabo (died 1496) was a Taíno cacique (chieftain) of Hispaniola at the time of Christopher Columbus's arrival to the island. He was known for his fighting skills and his ferocity. He was married to Anacaona, who was the sister of another cacique named . In retaliation against mistreatment of the Taíno people, Caonabo led attacks against the Spanish, including an assault on La Navidad which left 39 Spaniards dead. His capture in 1494 led to the first native American uprising against the Spanish rule. Caonabo died in Spanish captivity.