The former Castleberry Hotel is a historic commercial building at 61 Main Street (United States Route 70) in De Valls Bluff, Arkansas. It is a two-story masonry structure, built out of brick and capped by a hip roof whose eaves have exposed rafter tails. A porch extends across the sidewalk in front of the building, supported by brick piers. Built in 1925, it is a good local example of Craftsman architecture. It was the town's principal hotel, serving through travelers until the 1960s, when the town was bypassed by interstate highways.