Catahoula Creek is a stream in the U.S. state of Mississippi. It rises in Pearl River County, flows through Hancock County for about 25 miles where it becomes the flowing into the Bay of St. Louis. The creek has a Choctaw language name and a large Choctaw town, Center, once stood on its banks. Center was the county seat of Hancock until the expulsion of Native Americans from the South in the 1830s. Catahoula Creek has frequently been used for scientific studies of fish. Treasure hunters following rumors of buried treasure frequently dig holes in the banks.