Charles Christopher Frost (November 11, 1805 – March 16, 1880) was an American botanist. He described several species of fungi from the New England area of the United States. In one paper, Frost described 22 new species of boletes, and he was later credited with the discovery of three additional species. His personal herbarium of specimens were given to the University of Vermont in 1902. Portions of his collection today are distributed between the at Harvard University, the New York State Museum, the Bell Museum of Natural History, and the Buffalo Museum of Science.