Chloramphenicol acetyltransferase
Chloramphenicol acetyltransferase (or CAT) is a bacterial enzyme (EC 2.3.1.28) that detoxifies the antibiotic chloramphenicol and is responsible for chloramphenicol resistance in bacteria. This enzyme covalently attaches an acetyl group from acetyl-CoA to chloramphenicol, which prevents chloramphenicol from binding to ribosomes. A histidine residue, located in the C-terminal section of the enzyme, plays a central role in its catalytic mechanism.
Acetyl-CoA:chloramphenicol 3-O-acetyltransferaseAcetyltransferaseBonny Light oilCAT ICAT IICAT IIICat (disambiguation)Chloramphenical acetyl transferaseChloramphenicolChloramphenicol O-acetyltransferaseChloramphenicol acetyl transferaseChloramphenicol o-acetyltransferaseDihydrolipoyl transacetylaseEC 2.3.1.28GUS reporter systemIndex of molecular biology articlesList of EC numbers (EC 2)List of MeSH codes (D08)Reporter gene
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Chloramphenicol acetyltransferase
Chloramphenicol acetyltransferase (or CAT) is a bacterial enzyme (EC 2.3.1.28) that detoxifies the antibiotic chloramphenicol and is responsible for chloramphenicol resistance in bacteria. This enzyme covalently attaches an acetyl group from acetyl-CoA to chloramphenicol, which prevents chloramphenicol from binding to ribosomes. A histidine residue, located in the C-terminal section of the enzyme, plays a central role in its catalytic mechanism.
has abstract
Chloramphenicol acetyltransfer ...... a main-chain carbonyl oxygen.
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992,141,223
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Ribbon diagram of the chloramp ...... chloramphenicol bound. From .
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CAS number
9040-07-07
EC number
GO code
InterPro
IPR001707
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name
Chloramphenicol acetyltransferase
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PDB
G:6-209 A:6-209 B:6-20 ...... :1-205 :1-205 :1-205
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Pfam
PF00302
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PROSITE
PDOC00093
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symbol
CAT
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hypernym
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Chloramphenicol acetyltransfer ...... le in its catalytic mechanism.
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label
Chloramphenicol acetyltransferase
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