Christopher Cherniak is an American neuroscientist, a member of the University of Maryland Philosophy Department. Cherniak’s research trajectory started in theory of knowledge and led into computational neuroanatomy and genomics. The underlying linkage between the areas concerns models of the agent: The work began with more realistic, bounded-resource models of rationality. From this epistemology in turn stemmed a research program concerning optimal-wiring models of global brain and genome anatomy, a structuralist approach.