Coibamide A
Coibamide A is an antiproliferative depsipeptide which was isolated from a marine Leptolyngbya cyanobacterium. Testing of coibamide A in the National Cancer Institute in vitro 60 human tumor cell line panel (NCI-60) revealed potent anti-proliferative activity and a unique selectivity profile. Similarities between coibamide A- and apratoxin A-induced changes in cell morphology, decreases in VEGFR2 expression and macroautophagy signaling in HUVECs raise the possibility that both cyanobacterial natural products share a common mechanism of action. Wild-type mouse embryonic fibroblasts were more vulnerable to coibamide A than cells lacking autophagy-related protein 5 (Atg5) that suggest coibamide A as a compound with characteristics that may utilize autophagy for pro-death signaling.
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Coibamide A
Coibamide A is an antiproliferative depsipeptide which was isolated from a marine Leptolyngbya cyanobacterium. Testing of coibamide A in the National Cancer Institute in vitro 60 human tumor cell line panel (NCI-60) revealed potent anti-proliferative activity and a unique selectivity profile. Similarities between coibamide A- and apratoxin A-induced changes in cell morphology, decreases in VEGFR2 expression and macroautophagy signaling in HUVECs raise the possibility that both cyanobacterial natural products share a common mechanism of action. Wild-type mouse embryonic fibroblasts were more vulnerable to coibamide A than cells lacking autophagy-related protein 5 (Atg5) that suggest coibamide A as a compound with characteristics that may utilize autophagy for pro-death signaling.
has abstract
Coibamide A is an antiprolifer ...... tic properties of coibamide A.
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IUPAC name
N-{(2S)-2-[(N,N-Dimethyl-(L)-v ...... -N,N2-dimethyl-(L)-leucinamide
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Wikipage page ID
50,076,931
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1,011,410,490
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IUPACName
N-{-2-[oxy]-3-methylbutanoyl}- ...... -N,N2-dimethyl-(L)-leucinamide
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comment
Coibamide A is an antiprolifer ...... phagy for pro-death signaling.
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label
Coibamide A
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