Colestolone
Colestolone (INN, USAN), also known as 5α-cholest-8(14)-en-3β-ol-15-one, is a potent inhibitor of sterol biosynthesis which is described as a hypocholesterolemic (lipid-lowering) agent. It was first reported in 1977 and was studied until at least 1988, but was never introduced for medical use. In addition to its potent inhibition of cholesterol biosynthesis, it is notable that colestolone also happens to serve as a precursor of cholesterol, and is efficiently converted into it in rat liver homogenates and upon oral administration to rats.
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Colestolone
Colestolone (INN, USAN), also known as 5α-cholest-8(14)-en-3β-ol-15-one, is a potent inhibitor of sterol biosynthesis which is described as a hypocholesterolemic (lipid-lowering) agent. It was first reported in 1977 and was studied until at least 1988, but was never introduced for medical use. In addition to its potent inhibition of cholesterol biosynthesis, it is notable that colestolone also happens to serve as a precursor of cholesterol, and is efficiently converted into it in rat liver homogenates and upon oral administration to rats.
has abstract
Colestolone (INN, USAN), also ...... n oral administration to rats.
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CAS number
50673-97-7
FDA UNII code
5P8396T5XF
PubChem
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54,442,938
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994,910,620
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ChemSpiderID
IUPAC name
PubChem
SMILES
CCCCCC[C@H]1CCC2=C3CC[C@H]4C[C@H]O
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StdInChIKey
LINVVMHRTUSXHL-NDNSGUFDSA-N
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subject
comment
Colestolone (INN, USAN), also ...... n oral administration to rats.
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label
Colestolone
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