The Coley Building was a historic two-story commercial building in Mobile, Alabama, United States. It began as a one-story Federal style masonry structure in 1836. It was the last 19th century building to survive on its city block. The block, situated between the streets of St. Francis, Royal, Water, and St. Michael, was a center for many of Mobile's brokerage firms prior to the American Civil War. The building was seized by the Confederate government during the war from a suspected Union collaborator. It was enlarged and remodeled in the 1870s, with the addition of a second floor and the application of a Beaux-Arts-influenced cast iron facade.