The Columbia Southern Railway Passenger Station and Freight Warehouse is a historic train station at the intersection of Clark and Fulton Streets in Wasco, Oregon. The station was built in 1898 by the Columbia Southern Railway as part of a new line connecting inland Oregon to the Columbia River. The Wasco depot served both passenger and freight trains along the route, which reached as far south as Shaniko and spurred economic development in the region. While the Oregon Trunk Railway's new line to Bend became the main inland Oregon route in 1911, the Columbia Southern route continued to serve Sherman County as a local route. Passenger service to Wasco ended in 1936, and a 1964 flood damaged the line severely enough to permanently end freight services as well.