The Commercial Bank and Banker's House is an unusual combination building, housing both a bank premises and the principal banker's residence, at 206 Main Street and 107 Canal Street in Natchez, Mississippi. Built-in 1833, it is a remarkably high-quality and well-preserved example of Greek Revival architecture. It was designated a National Historic Landmark in 1974. The bank portion of the building, used for a time by a Christian Science congregation, is presently vacant, while the house portion is a private residence.