Constitutive androstane receptor
The constitutive androstane receptor (CAR) also known as nuclear receptor subfamily 1, group I, member 3 is a protein that in humans is encoded by the NR1I3 gene. CAR is a member of the nuclear receptor superfamily and along with pregnane X receptor (PXR) functions as a sensor of endobiotic and xenobiotic substances. In response, expression of proteins responsible for the metabolism and excretion of these substances is upregulated. Hence, CAR and PXR play a major role in the detoxification of foreign substances such as drugs.
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ABCC3AndrostenolCar (disambiguation)Cyproconazole1,2-dimethoxyethaanEvolution of the vitamin D receptorHepatocyte nuclear factor 4 alphaList of androstanesList of human protein-coding genes 3NR1I3NR1I3 (gene)Nuclear receptorPerfluorooctanoic acidPhenobarbital1,2-dimethoxyethaanPrimidoneRetinoid X receptorTriclocarbanXenobiotic-sensing receptor
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Constitutive androstane receptor
The constitutive androstane receptor (CAR) also known as nuclear receptor subfamily 1, group I, member 3 is a protein that in humans is encoded by the NR1I3 gene. CAR is a member of the nuclear receptor superfamily and along with pregnane X receptor (PXR) functions as a sensor of endobiotic and xenobiotic substances. In response, expression of proteins responsible for the metabolism and excretion of these substances is upregulated. Hence, CAR and PXR play a major role in the detoxification of foreign substances such as drugs.
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The constitutive androstane re ...... endogenous agonist of the CAR.
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The constitutive androstane re ...... eign substances such as drugs.
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Constitutive androstane receptor
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