Crosstown Expressway may refer to: * Crosstown Expressway (Interstate 494), a proposed highway route in Chicago, Illinois, United States * Crosstown Expressway (Philadelphia), an unbuilt highway in Philadelphia that was to be a part of Interstate 695 * Crosstown Expressway (Toronto), a cancelled expressway project in Toronto, Ontario, Canada * A portion of Interstate 244 in Tulsa, Oklahoma, United States, known as the Crosstown Expressway * Interstate 579 in Pittsburgh, an expressway known as the Crosstown Boulevard * Lee Roy Selmon Crosstown Expressway, a limited access toll road in Hillsborough County, Florida, United States * Minnesota State Highway 62 (east), referred to locally as the Crosstown * Oklahoma City Crosstown Expressway, a section of Interstate 40 in Oklahoma City,