Cyclotraxin B
Cyclotraxin B (CTX-B) is a small (1200 Da) cyclic peptide and highly potent, selective, non-competitive antagonist or negative allosteric modulator of TrkB (IC50 = 0.30 nM), the main receptor of brain-derived neurotrophic factor (BDNF), which itself was derived from BDNF. It crosses the blood-brain-barrier with systemic administration and produces anxiolytic-like effects in animals, though notably not antidepressant-like effects. The compound has also been found to produce analgesic effects in animal models of neuropathic pain. In addition to TrkB, CTX-B has been found to be an allosteric modulator of VEGFR2, one of the receptors of vascular endothelial growth factor (VEGF).
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Cyclotraxin B
Cyclotraxin B (CTX-B) is a small (1200 Da) cyclic peptide and highly potent, selective, non-competitive antagonist or negative allosteric modulator of TrkB (IC50 = 0.30 nM), the main receptor of brain-derived neurotrophic factor (BDNF), which itself was derived from BDNF. It crosses the blood-brain-barrier with systemic administration and produces anxiolytic-like effects in animals, though notably not antidepressant-like effects. The compound has also been found to produce analgesic effects in animal models of neuropathic pain. In addition to TrkB, CTX-B has been found to be an allosteric modulator of VEGFR2, one of the receptors of vascular endothelial growth factor (VEGF).
has abstract
Cyclotraxin B (CTX-B) is a sma ...... othelial growth factor (VEGF).
@en
CAS number
1203586-72-4
PubChem
Wikipage page ID
49,040,338
page length (characters) of wiki page
Wikipage revision ID
975,238,103
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ATC prefix
None
@en
CAS number
ChemSpiderID
29,785,020
IUPAC name
PubChem
90,489,002
SMILES
CCO
@en
StdInChIKey
JLBMMJHZUYBFGX-ZHTCEXBHSA-N
@en
synonyms
CTX-B
@en
wikiPageUsesTemplate
hypernym
comment
Cyclotraxin B (CTX-B) is a sma ...... othelial growth factor (VEGF).
@en
label
Cyclotraxin B
@en