Cysmethynil
Cysmethynil is a chemical compound that is reported to inhibit Icmt, a protein that methylates a Ras protein, which then triggers uncontrolled cell growth. If Icmt no longer activates Ras, cell growth and proliferatation remains under normal control. As such, this small molecule has been investigated as a treatment for cancer. In animal models containing multiple human tumor growths, treatment with cysmethynil causes autophagy in the cell and results in cell death and reduced tumor burden. In prostate cancer cells, cysmethynil inhibits Icmt such that the cell is stuck in the G1 phase, and this leads to the autophagic cell death.
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Cysmethynil
Cysmethynil is a chemical compound that is reported to inhibit Icmt, a protein that methylates a Ras protein, which then triggers uncontrolled cell growth. If Icmt no longer activates Ras, cell growth and proliferatation remains under normal control. As such, this small molecule has been investigated as a treatment for cancer. In animal models containing multiple human tumor growths, treatment with cysmethynil causes autophagy in the cell and results in cell death and reduced tumor burden. In prostate cancer cells, cysmethynil inhibits Icmt such that the cell is stuck in the G1 phase, and this leads to the autophagic cell death.
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Cysmethynil is a chemical comp ...... to the autophagic cell death.
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alternative name
Cysmethynil, 2-(1-octyl-5-m-tolyl-1H-indol-3-yl)acetamide, 9J20
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IUPAC name
2-[5-(3-Methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
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InternetArchiveBot
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date
July 2019
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yes
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OtherNames
Cysmethynil, 2-acetamide, 9J20
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Cysmethynil is a chemical comp ...... to the autophagic cell death.
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label
Cysmethynil
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