DNA end resection
DNA end resection, also called 5′–3′ degradation, is a biochemical process where the blunt end of a section of double-stranded DNA is modified by cutting away some nucleotides from the 5' end to produce a 3' single-stranded sequence. It is an important part of the repair mechanism of double-stranded breaks (DSB) of the DNA molecule: two of the three main mechanisms for repair of DSBs, microhomology-mediated end joining (MMEJ) and homologous recombination (HR) rely on end resection. The presence of a section of single-stranded DNA (ssDNA) allows the broken end of the DNA to line up accurately with a matching sequence, so that it can be accurately repaired.
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DNA end resection
DNA end resection, also called 5′–3′ degradation, is a biochemical process where the blunt end of a section of double-stranded DNA is modified by cutting away some nucleotides from the 5' end to produce a 3' single-stranded sequence. It is an important part of the repair mechanism of double-stranded breaks (DSB) of the DNA molecule: two of the three main mechanisms for repair of DSBs, microhomology-mediated end joining (MMEJ) and homologous recombination (HR) rely on end resection. The presence of a section of single-stranded DNA (ssDNA) allows the broken end of the DNA to line up accurately with a matching sequence, so that it can be accurately repaired.
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DNA end resection, also called ...... it can be accurately repaired.
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DNA end resection, also called ...... it can be accurately repaired.
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DNA end resection
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