David Barclay of Cheapside (1682–1769) was a Scottish merchant and banker. He was the second son of Robert Barclay, the Scottish Quaker writer, and was active in the Society of Friends. An apprentice in London in 1698, he became a leading linen merchant. Involved in banking through a family connection with John Freame, father of his second wife, Barclay was not directly concerned with the firm that much later became Barclays Bank; but two of his sons were, John and David Barclay of Youngsbury, who famously manumitted his slaves.