Death-inducing signaling complex
The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors. A typical example is FasR, which forms the DISC upon trimerization as a result of its ligand (FasL) binding. The DISC is composed of the death receptor, FADD, and caspase 8. It transduces a downstream signal cascade resulting in apoptosis.
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Activation-induced cell deathAnticancer geneApoptosisCaspaseDNA damage-inducible transcript 3Death Inducing Signaling ComplexDeath Inducing Signalling ComplexDeath effector domainDeath inducing signaling complexDeath inducing signalling complexDiscExtrinsic pathwayFADDFas ligandFas receptorMyristoylationTRPV2
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Death-inducing signaling complex
The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors. A typical example is FasR, which forms the DISC upon trimerization as a result of its ligand (FasL) binding. The DISC is composed of the death receptor, FADD, and caspase 8. It transduces a downstream signal cascade resulting in apoptosis.
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The death-inducing signaling c ...... ascade resulting in apoptosis.
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The death-inducing signaling c ...... ascade resulting in apoptosis.
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Death-inducing signaling complex
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