John F. "Denny" Driscoll (November 19, 1855 – July 11, 1886) was an American Major League Baseball pitcher from 1880 to 1884. Driscoll played for the Buffalo Bisons, Pittsburgh Alleghenys (the modern-day Pittsburgh Pirates), and Louisville Eclipse. While playing for Pittsburgh, he led the American Association in earned run average in 1882, at 1.21. He went 13-9 that season. In 1883, he was the primary pitcher for the Alleghenys' for most of the season with an 18-21 record, and was the opening day starting pitcher.