Diploidization is the process of converting a polyploid genome back into a diploid one. Polyploidy is a product of whole genome duplication (WGD) and is followed by diploidization as a result of genome shock. The plant kingdom has undergone multiple events of polyploidization followed by diploidization in both ancient and recent lineages. It has also been hypothesized that vertebrate genomes have gone through two rounds of paleopolyploidy. The mechanisms of diploidization are poorly understood but patterns of chromosomal loss and evolution of novel genes are observed in the process.