Domenico di Michelino (1417–1491) was an Italian Renaissance painter who was born and died in Florence. His real name was Domenico di Francesco. The patronymic "di Michelino" was adopted in honor of his teacher, the cassone painter Michelino di Benedetto (c. 1378-1499), by whom no works have been identified. Giorgio Vasari reports that Domenico was also a pupil of Fra Angelico, whose influence is reflected in many of Domenico's paintings along with that of Filippo Lippi and Pesellino.