Ebrotidine
Ebrotidine is an H2 receptor antagonist with gastroprotective activity against ethanol-, aspirin- or stress-induced gastric mucosal damage. The antisecretory properties of ebrotidine are similar to those of ranitidine, and approximately 10-fold greater than those of cimetidine. Ebrotidine has anti-Helicobacter pylori activity via inhibition of the urease enzyme and the proteolytic and mucolytic activities of the bacterium. However, its activity is synergistic with a number of antibacterial agents. Ebrotidine counteracts the inhibitory effects of H. pylori lipopolysaccharides. Ebrotidine was withdrawn from the market due to risks of hepatotoxicity.
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Ebrotidine
Ebrotidine is an H2 receptor antagonist with gastroprotective activity against ethanol-, aspirin- or stress-induced gastric mucosal damage. The antisecretory properties of ebrotidine are similar to those of ranitidine, and approximately 10-fold greater than those of cimetidine. Ebrotidine has anti-Helicobacter pylori activity via inhibition of the urease enzyme and the proteolytic and mucolytic activities of the bacterium. However, its activity is synergistic with a number of antibacterial agents. Ebrotidine counteracts the inhibitory effects of H. pylori lipopolysaccharides. Ebrotidine was withdrawn from the market due to risks of hepatotoxicity.
has abstract
Ebrotidine is an H2 receptor a ...... xplicably) in those who smoke.
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CAS number
100981-43-9
ChEMBL
FDA UNII code
TMZ3IBW2OW
PubChem
Wikipage page ID
26,911,349
page length (characters) of wiki page
Wikipage revision ID
963,845,119
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CAS number
ChEMBL
ChemSpiderID
IUPAC name
N-sulfonyl-N'-[2-[[2--1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide
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PubChem
routes of administration
Oral
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SMILES
Brc1cccSN/C=N/CCSCc2cscN=CN
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StdInChIKey
ZQHFZHPUZXNPMF-UHFFFAOYSA-N
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UNII
TMZ3IBW2OW
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Verifiedfields
changed
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verifiedrevid
451,556,318
Watchedfields
changed
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wikiPageUsesTemplate
subject
hypernym
comment
Ebrotidine is an H2 receptor a ...... ue to risks of hepatotoxicity.
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label
Ebrotidine
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