Elaine Sarkin Jaffe (born in August 1943) is a senior National Cancer Institute (NCI) investigator at the National Institutes of Health (NIH) most well known for her contribution to hematopathology. She completed her medical education at Cornell University and the University of Pennsylvania, receiving her M.D. degree from University of Pennsylvania in 1969. After an internship at Georgetown University she joined NCI as a resident in anatomic pathology, and has been a senior investigator since 1974, focusing on the classification and definition of lymphomas. Jaffe's early work helped to provide a deeper understanding of the origin of lymphomas, especially follicular lymphoma. Her team notably elucidated the difference between T cell and B cell lymphomas.