Elisha Cooke Jr. (December 20, 1678 – August 24, 1737) was a physician and politician from the Province of Massachusetts Bay. He was the son of Elisha Cooke Sr. (1637–1715), a wealthy Massachusetts physician and politician who was elected Speaker of the Massachusetts House of Representatives in 1683. He graduated from Harvard University in 1697. Cooke worked closely with Samuel Adams Sr. (1689–1748), whose son Samuel Adams would continue the struggle to defend colonial rights, ultimately leading to the American Revolution.