Enprostil
Enprostil is a synthetic prostaglandin designed to resemble dinoprostone. Enprostil was found to be a highly potent inhibitor of gastric HCl secretion. It is an analog of prostaglandin E2 but unlike this prostaglandin, which binds to and activates all four cellular receptors viz., EP1, EP2, EP3, and EP4 receptors, enprostil is a more selective receptor agonist in that it binds to and activates primarily the EP3 receptor. Consequently, enprostil is expected to have a narrower range of actions that may avoid some of the unwanted side-effects and toxicities of prostaglandin E2. A prospective multicenter randomized controlled trial conducted in Japan found combining enprostil with cimetidine was more effective than cimetidine alone in treating gastric ulcer.
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Enprostil
Enprostil is a synthetic prostaglandin designed to resemble dinoprostone. Enprostil was found to be a highly potent inhibitor of gastric HCl secretion. It is an analog of prostaglandin E2 but unlike this prostaglandin, which binds to and activates all four cellular receptors viz., EP1, EP2, EP3, and EP4 receptors, enprostil is a more selective receptor agonist in that it binds to and activates primarily the EP3 receptor. Consequently, enprostil is expected to have a narrower range of actions that may avoid some of the unwanted side-effects and toxicities of prostaglandin E2. A prospective multicenter randomized controlled trial conducted in Japan found combining enprostil with cimetidine was more effective than cimetidine alone in treating gastric ulcer.
has abstract
Enprostil is a synthetic prost ...... one in treating gastric ulcer.
@en
إنبروستيل Enprostil هو بروستاغ ...... لتثبيط لحمض كلور الماء المعدي.
@ar
恩前列素是一種合成的類地諾前列酮前列腺素,它可以用來作胃部HCl分泌的強效抑制劑。 因而常被用來作抗酸或潰瘍藥。它的藥理作用基本與米索前列醇相同。
@zh
CAS number
73121-56-9
FDA UNII code
J4IP5Z9DAU
KEGG
PubChem
Wikipage page ID
page length (characters) of wiki page
Wikipage revision ID
1,011,270,159
Link from a Wikipage to another Wikipage
ATC prefix
A02
@en
ATC suffix
BB02
@en
CAS number
ChemSpiderID
IUPAC name
methyl 7-[-3-hydroxy-2-[-3-hyd ...... cyclopentyl]hepta-4,5-dienoate
@en
KEGG
D01891
@en
PubChem
SMILES
COCCCC=C=CC[C@@H]1[C@H]/C=C/[C@H]O
@en
StdInChIKey
PTOJVMZPWPAXER-VFJVYMGBSA-N
@en
UNII
J4IP5Z9DAU
@en
verifiedrevid
447,573,683
Watchedfields
changed
@en
wikiPageUsesTemplate
hypernym
comment
Enprostil is a synthetic prost ...... one in treating gastric ulcer.
@en
إنبروستيل Enprostil هو بروستاغ ...... لتثبيط لحمض كلور الماء المعدي.
@ar
恩前列素是一種合成的類地諾前列酮前列腺素,它可以用來作胃部HCl分泌的強效抑制劑。 因而常被用來作抗酸或潰瘍藥。它的藥理作用基本與米索前列醇相同。
@zh
label
Enprostil
@en
إنبروستيل
@ar
恩前列素
@zh