Erythropoietin receptor
The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a single carbohydrate chain resulting in an approximately 56-57 kDa protein found on the surface of EPO responding cells. It is a member of the cytokine receptor family. EpoR pre-exists as dimers which upon binding of a 30 kDa ligand erythropoietin (Epo), changes its homodimerized state. These conformational changes result in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor (i.e., EpoR does not possess intrinsic kinase activity and depends on Jak2 activity). At present, the most well-established function of EpoR is to promote proliferation and rescue of erythroid (red blood cell) progenitors from apoptosis.
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Alan D'AndreaCISHCRKLClonal hypereosinophiliaCytokine receptorDarbepoetin alfaDoug HiltonEPOREPOR (gene)Eero MäntyrantaEpo-RErythropoietinFLI1Fibronectin type III domainGRB2GlycosylationGranulocyte-macrophage colony-stimulating factor receptorHarvey LodishIndex of biochemistry articlesIndex of immunology articlesJAK-STAT signaling pathwayJanus kinase 21,2-dimethoxyethaanList of MeSH codes (D12.776.543)List of human hormonesList of human protein-coding genes 2Methoxy polyethylene glycol-epoetin betaNon-receptor tyrosine kinaseOutline of immunologyPCM1PIK3R1PTPN6PolycythemiaProerythroblastReceptors, erythropoietinSH2B3SOCS2SOCS3STAT5ASatellite glial cell
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Erythropoietin receptor
The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a single carbohydrate chain resulting in an approximately 56-57 kDa protein found on the surface of EPO responding cells. It is a member of the cytokine receptor family. EpoR pre-exists as dimers which upon binding of a 30 kDa ligand erythropoietin (Epo), changes its homodimerized state. These conformational changes result in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor (i.e., EpoR does not possess intrinsic kinase activity and depends on Jak2 activity). At present, the most well-established function of EpoR is to promote proliferation and rescue of erythroid (red blood cell) progenitors from apoptosis.
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The erythropoietin receptor (E ...... l) progenitors from apoptosis.
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The erythropoietin receptor (E ...... l) progenitors from apoptosis.
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Erythropoietin receptor
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