Fialuridine
Fialuridine, or 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU), is a nucleoside analogue that was investigated as a potential therapy for hepatitis B virus infection. In a 1993 clinical study at the NIH, unexpected toxicity led to the death of 5 out of 15 patients from liver failure alongside lactic acidosis; two further participants required liver transplantation. This toxicity was unusual in that it was not predicted by animal studies. It is suspected that the drug's toxicity was due to its ability to damage mitochondria.
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Fialuridine
Fialuridine, or 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU), is a nucleoside analogue that was investigated as a potential therapy for hepatitis B virus infection. In a 1993 clinical study at the NIH, unexpected toxicity led to the death of 5 out of 15 patients from liver failure alongside lactic acidosis; two further participants required liver transplantation. This toxicity was unusual in that it was not predicted by animal studies. It is suspected that the drug's toxicity was due to its ability to damage mitochondria.
has abstract
Fialuridine, or 1-(2-deoxy-2-f ...... bility to damage mitochondria.
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CAS number
69123-98-4
ChEMBL
FDA UNII code
53T7IN77LC
KEGG
PubChem
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Wikipage page ID
16.738.992
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1.010.099.405
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alt
Ball-and-stick model
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Skeletal formula
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ATC prefix
none
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CAS number
ChEMBL
ChemSpiderID
image
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IUPAC name
KEGG
D04181
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NIAID ChemDB
PubChem
SMILES
c1cI
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StdInChIKey
IPVFGAYTKQKGBM-BYPJNBLXSA-N
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Verifiedfields
changed
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verifiedrevid
443.996.139
Watchedfields
changed
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wikiPageUsesTemplate
subject
hypernym
comment
Fialuridine, or 1-(2-deoxy-2-f ...... bility to damage mitochondria.
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label
Fialuridine
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