The Florence Griswold Museum is an Art Museum at 96 Lyme Street in Old Lyme, Connecticut centered on the home of Florence Griswold (1850–1937), which was the center of the Old Lyme Art Colony, a main nexus of American Impressionism. The Museum is noted for its collection of American Impressionist paintings. The house was designated a National Historic Landmark in 1993. The site encompasses 12-acres of historic buildings, grounds, gardens, and walking trails.