Formyl peptide receptor
The formyl peptide receptors (FPR) belong to a class of G protein-coupled receptors involved in chemotaxis. In humans, there are three formyl peptide receptor isoforms, each encoded by a separate gene that are named FPR1, FPR2, and FPR3. These receptors were originally identified by their ability to bind N-formyl peptides such as N-formylmethionine produced by the degradation of either bacterial or host cells. Hence formyl peptide receptors are involved in mediating immune cell response to infection. These receptors may also act to suppress the immune system under certain conditions. The close phylogenetic relation of signaling in chemotaxis and olfaction was recently proved by detection formyl peptide receptor like proteins as a distinct family of vomeronasal organ chemosensors in mice.
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Formyl peptide receptor
The formyl peptide receptors (FPR) belong to a class of G protein-coupled receptors involved in chemotaxis. In humans, there are three formyl peptide receptor isoforms, each encoded by a separate gene that are named FPR1, FPR2, and FPR3. These receptors were originally identified by their ability to bind N-formyl peptides such as N-formylmethionine produced by the degradation of either bacterial or host cells. Hence formyl peptide receptors are involved in mediating immune cell response to infection. These receptors may also act to suppress the immune system under certain conditions. The close phylogenetic relation of signaling in chemotaxis and olfaction was recently proved by detection formyl peptide receptor like proteins as a distinct family of vomeronasal organ chemosensors in mice.
has abstract
The formyl peptide receptors ( ...... sic and Clinical Pharmacology.
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chromosome
EntrezGene
HGNCid
OMIM id
RefSeq
Symbol
ALXR, FMLPX, FPR2/ALX, FPR2A, FPRH1, FPRL1, HM63, LXA4R, RFP
FPRH2, FPRL2, FMLPY
UniProt
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997,524,419
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AltSymbols
ALXR, FMLPX, FPR2/ALX, FPR2A, FPRH1, FPRL1, HM63, LXA4R, RFP
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FPR; FMLP
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FPRH2, FPRL2, FMLPY
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Arm
q
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Chromosome
EntrezGene
HGNCid
OMIM
RefSeq
NM_001462
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NM_002029
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NM_002030
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symbol
FPR1
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FPR2
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FPR3
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UniProt
P21462
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P25089
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P25090
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wikiPageUsesTemplate
subject
comment
The formyl peptide receptors ( ...... al organ chemosensors in mice.
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label
Formyl peptide receptor
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sameAs
wasDerivedFrom
isPrimaryTopicOf
name
formyl peptide receptor 1
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formyl peptide receptor 2
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formyl peptide receptor 3
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