Four Mounds Estate Historic District is a nationally recognized historic district located in Dubuque, Iowa, United States. It was listed on the National Register of Historic Places in 2002. At the time of its nomination the district consisted of 19 resources, including 11 contributing buildings, two contributing sites, four non-contributing structures, and two non-contributing buildings. The estate is named for the four conical burial mounds that are located on the property. They are one of the historic sites, and they are individually listed on the National Register of Historic Places.