Francesco I Manfredi (died May 29, 1343) was the lord of Faenza from 1313 until his death. He was the son of Alberghetto (or Alberghettino) Manfredi, one of the main Guelph leader of Romagna, from whom he inherited the lordships of Brisighella, Quarneto, and Baccagnano, to which Francesco added other lands starting from 1309. He married Rengarda Malatesta, daughter of Malatesta I Malatesta of Rimini. Francesco Manfredi died at Faenza in 1343. He left nine children, including the future seigniors of Faenza , , and .