Francesco Vitelli (1586–1646) was a Roman Catholic ecclesiastic in the papal service. Vitelli was born in Città di Castello. He was made titular archbishop of Thessalonica (16 August 1632), then successively transferred to Terni (1634) and to Urbino (1636) and appointed papal nuncio to the Republic of Venice. In 1643 Pope Urban VIII Barberini appointed him Governor of Rome, an honorary position that his absence as bishop of Urbino disabled him from taking up. He was a correspondent of the papal diplomat Guido Bentivoglio, who addressed to him his Relationi concerning Flanders, 1633.