Francis Eyles (c.1679 - 19 December 1735), of Essex Street, London, and , near Taunton, Somerset, was an English Whig politician who sat in the House of Commons from 1715 to 1721. Eyles was the son of Sir John Eyles of Southbroom, Wiltshire, briefly Lord Mayor of London in 1688. Eyles died in 1735, leaving no children. He left the remainder of his personal estate to his nephew Francis.