Several small RNAs have been identified in Francisella tularensis, pathogenic bacterium that causes the disease tularaemia. Very little is known about Francisella's regulatory networks that allow this bacterium to survive in many environments. FtrC (Francisella tularensis sRNA C) is the first sRNA shown to modulate the virulence capacity of F. tularensis. High expression of FtrC reduces intracellular multiplication of the bacteria in macrophages and in organs of infected mice. FtrC mRNA target gene was also identified, but it is not involved in Francisella multiplication.