GMP synthase
Guanosine monophosphate synthetase, (EC 6.3.5.2) also known as GMPS is an enzyme that converts xanthosine monophosphate to guanosine monophosphate. In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.
Circulating free DNAEC 6.3.4.1EC 6.3.5.2GMPSGMPS (gene)GMP synthase (glutamine-hydrolysing)GMP synthase (glutamine—hydrolysing)GMP synthetaseGlutamine amidotransferaseGuanine monphosphate synthetaseList of EC numbers (EC 6)List of OMIM disorder codesList of human protein-coding genes 2Purine metabolismValaciclovirXanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)Xanthosine monophosphate
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GMP synthase
Guanosine monophosphate synthetase, (EC 6.3.5.2) also known as GMPS is an enzyme that converts xanthosine monophosphate to guanosine monophosphate. In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.
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Guanosine monophosphate synthe ...... s the amination of XMP to GMP.
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EC number
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11,288,874
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992,472,791
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caption
GMP synthetase, human
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escherichia coli gmp synthetase complexed with amp and pyrophosphate.
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CAS number
EC number
GO code
InterPro
IPR001674
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IUBMB EC number
name
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GMP synthetase C terminal domain
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GMP synthetase
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Pfam
PF00958
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PROSITE
PDOC00405
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symbol
GMP_synt_C
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comment
Guanosine monophosphate synthe ...... s the amination of XMP to GMP.
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label
GMP synthase
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name
(glutamine-hydrolyzing)
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GMP synthetase
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