G protein-coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Ligands can bind either to extracellular N-terminus and loops (e.g. glutamate receptors) or to the binding site within transmembrane helices (Rhodopsin-like family). They are all activated by agonists although a spontaneous auto-activation of an empty receptor can also be observed.
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7-transmembrane7-transmembrane G-protein coupled7-transmembrane receptor7TM7TM Receptor7TM receptor7 transmembrane7 transmembrane receptorG-protein-coupledG-protein-coupled receptorG-protein-coupled receptorsG-protein coupledG-protein coupled membrane receptorsG-protein coupled receptorG-protein coupled receptorsG-protein linked receptorsGPCRGPCRsG protein-coupledG protein-coupled receptorsG protein coupled receptorG protein coupled receptorsG protein–coupled receptorGi coupled receptorGpcrGpcrsGuanine Nucleotide-Binding Protein-Coupled ReceptorHeptahelical receptorReceptors, g-protein-coupledSerpentine receptorSeven-transmembrane proteinSeven transmembrane proteinSeven transmembrane receptorSeven transmembrane region
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12-Hydroxyeicosatetraenoic acid12-Hydroxyheptadecatrienoic acid15-Hydroxyeicosatetraenoic acid2012 in the United States3-Hydroxyoctanoic acid3-Iodothyronamine5-HT1A receptor5-HT1D receptor5-HT1 receptor5-HT2A receptor5-HT2C receptor5-HT2C receptor agonist5-HT2 receptor5-HT3 receptor5-HT4 receptor5-HT5B receptor5-HT6 receptor5-HT7 receptor5-HT receptor5-Hydroxyeicosatetraenoic acid5-Oxo-eicosatetraenoic acid7-transmembrane7-transmembrane G-protein coupled7-transmembrane receptor7TM7TM Receptor7TM receptor7 transmembrane7 transmembrane receptorACKR3ACTH receptorADCY9ADCYAP1R1AKAP13ALOX15AMN082ARHGEF1ARHGEF11ARHGEF12ARHGEF4
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G protein-coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Ligands can bind either to extracellular N-terminus and loops (e.g. glutamate receptors) or to the binding site within transmembrane helices (Rhodopsin-like family). They are all activated by agonists although a spontaneous auto-activation of an empty receptor can also be observed.
has abstract
Els receptors acoblats a prote ...... 40% dels medicaments moderns.
@ca
G protein-coupled receptors (G ...... f the pharmaceutical research.
@en
G-proteinkopplade receptorer ä ...... ceptorer
* glutamatreceptorer
@sv
G-proteïnegekoppelde receptore ...... een GPCR als aangrijpingspunt.
@nl
G-білокспряжені рецептори (GPC ...... ри ангіотензинових рецепторів.
@uk
Gタンパク質共役受容体(ジータンパクしつきょうやくじゅようた ...... 割がGタンパク質共役受容体のうちのいずれかを標的としている。
@ja
G蛋白偶联受体(G Protein-Coupled Rece ...... )作为第二信使, 详见环腺苷酸信号通路和磷脂酰肌醇信号通路。
@zh
I recettori accoppiati alle pr ...... degli oppiacei e delle purine.
@it
Les récepteurs couplés aux pro ...... rmones et neurotransmetteurs).
@fr
Los receptores acoplados a pro ...... de su GDP enlazado por un GTP.
@es
Symbol
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1,021,836,742
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caption
The human beta-2 adrenergic re ...... ial inverse agonist carazolol.
@en
CDD
cd14964
@en
date
2015-04-03
2016-02-01
InterPro
IPR000276
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name
GPCR
@en
OPM family
OPM protein
Pfam
PF00001
@en
PROSITE
PDOC00210
@en
wikiPageUsesTemplate
subject
comment
Els receptors acoblats a prote ...... i varien des de la mida de mol
@ca
G protein-coupled receptors (G ...... receptor can also be observed.
@en
G-proteinkopplade receptorer ä ...... -proteinkopplade receptorer är
@sv
G-proteïnegekoppelde receptore ...... een GPCR als aangrijpingspunt.
@nl
G-білокспряжені рецептори (GPC ...... ри ангіотензинових рецепторів.
@uk
Gタンパク質共役受容体(ジータンパクしつきょうやくじゅようた ...... 割がGタンパク質共役受容体のうちのいずれかを標的としている。
@ja
G蛋白偶联受体(G Protein-Coupled Rece ...... 数众多,并且大约40%的现代药物都以G蛋白偶联受体作为靶点。
@zh
I recettori accoppiati alle pr ...... degli oppiacei e delle purine.
@it
Les récepteurs couplés aux pro ...... ortance thérapeutique majeure.
@fr
Los receptores acoplados a pro ...... mo la visión, el olfato, el gu
@es
label
G protein-coupled receptor
@en
G 단백질 연결 수용체
@ko
G-Protein-gekoppelte Rezeptoren
@de
G-proteinkopplade receptorer
@sv
G-proteïnegekoppelde receptor
@nl
G-білокспряжені рецептори
@uk
GPCR
@ru
Gタンパク質共役受容体
@ja
G蛋白偶联受体
@zh
Receptor acoblat a proteïnes G
@ca