Gaius Vettius Cossinius Rufinus (fl. 306 – 316) was a politician and senator of the late Roman Empire. In 306 he was made proconsul of Achaea, but Maxentius' revolt in Rome prevented Rufinus from taking up the post, since Maxentius did not have jurisdiction in Achaea. He was curator (i.e., official in charge of maintenance) of the via Flaminia, of the Tiber riverbed and of Rome's drains, corrector, or governor, of Regio X Venetia et Histria, the province of Diocletian that covered Tuscia Umbria and Campania, all under Maxentius.