Gastric chief cell

A gastric chief cell (or peptic cell, or gastric zymogenic cell) is a type of gastric gland cell that releases pepsinogen and gastric lipase and is the cell responsible for secretion of chymosin in ruminants. The cell stains basophilic upon H&E staining due to the large proportion of rough endoplasmic reticulum in its cytoplasm. Gastric chief cells are generally located deep in the mucosal layer of the stomach lining. It works in conjunction with the parietal cell, which releases gastric acid, converting the pepsinogen into pepsin.

Gastric chief cell

A gastric chief cell (or peptic cell, or gastric zymogenic cell) is a type of gastric gland cell that releases pepsinogen and gastric lipase and is the cell responsible for secretion of chymosin in ruminants. The cell stains basophilic upon H&E staining due to the large proportion of rough endoplasmic reticulum in its cytoplasm. Gastric chief cells are generally located deep in the mucosal layer of the stomach lining. It works in conjunction with the parietal cell, which releases gastric acid, converting the pepsinogen into pepsin.