George Doukas Philanthropenos (Greek: Γεώργιος Δούκας Φιλανθρωπηνός; died before 1452) was a close confidant of Byzantine Emperor John VIII Palaiologos (r. 1425–1448) and served briefly as mesazon (chief minister) of the Byzantine Empire in 1438–1439. He was a relative of the Patriarch of Constantinople Joseph II, who died in 1439 during the Council. George left an endowment to the church of Santa Maria Novella in Florence, where Joseph was buried, for an annual mass in his memory.