George Sykes (October 9, 1822 – February 8, 1880) was a career United States Army officer and a Union General during the American Civil War. He graduated from the United States Military Academy in 1842, and served in numerous conflicts, including the Second Seminole War and the Mexican–American War. During the Civil War, he was appointed commander of the 2nd Division of the V Corps of the Army of the Potomac during the Peninsula Campaign of 1862, and continued in that role through the Second Battle of Bull Run, the Battle of Antietam, the Battle of Fredericksburg, and the Battle of Chancellorsville.