Glucagon-like peptide-1 receptor
The glucagon-like peptide-1 receptor (GLP1R) is a receptor protein found on beta cells of the pancreas and on neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion. In humans it is synthesised by the gene GLP1R, which is present on chromosome 6. It is a member of the glucagon receptor family of G protein-coupled receptors. GLP1R is composed of two domains, one extracellular (ECD) that binds the C-terminal helix of GLP-1, and one transmembrane (TMD) domain that binds the N-terminal region of GLP-1. In the TMD domain there is a fulcrum of polar residues that regulates the biased signaling of the receptor while the transmembrane helical boundaries and extracellular surface are a trigger for biased agonism.
AlbiglutideGLP-1 receptorGLP1RGLP1R (gene)GLP1 receptorGlucagon-like peptide-1Glucagon-like peptide-1 receptor agonistGlucagon-like peptide-2 receptorGlucagon-like peptide 1 receptorGlucagon-like peptide receptorGlucagon receptor familyInterleukin 6List of human hormonesList of human protein-coding genes 2List of signaling peptide/protein receptor modulatorsLixisenatideMfsd5Neointimal hyperplasiaNeurotransmitterSecretin receptor family
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Glucagon-like peptide-1 receptor
The glucagon-like peptide-1 receptor (GLP1R) is a receptor protein found on beta cells of the pancreas and on neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion. In humans it is synthesised by the gene GLP1R, which is present on chromosome 6. It is a member of the glucagon receptor family of G protein-coupled receptors. GLP1R is composed of two domains, one extracellular (ECD) that binds the C-terminal helix of GLP-1, and one transmembrane (TMD) domain that binds the N-terminal region of GLP-1. In the TMD domain there is a fulcrum of polar residues that regulates the biased signaling of the receptor while the transmembrane helical boundaries and extracellular surface are a trigger for biased agonism.
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The glucagon-like peptide-1 re ...... a trigger for biased agonism.
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The glucagon-like peptide-1 re ...... a trigger for biased agonism.
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Glucagon-like peptide-1 receptor
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