Glutamate dehydrogenase 1
GLUD1 (glutamate dehydrogenase 1) is a mitochondrial matrix enzyme, one of the family of glutamate dehydrogenases that are ubiquitous in life, with a key role in nitrogen and glutamate (Glu) metabolism and energy homeostasis. This dehydrogenase is expressed at high levels in liver, brain, pancreas and kidney, but not in muscle. In the pancreatic cells, GLUD1 is thought to be involved in insulin secretion mechanisms. In nervous tissue, where glutamate is present in concentrations higher than in the other tissues, GLUD1 appears to function in both the synthesis and the catabolism of glutamate and perhaps in ammonia detoxification.
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1,2-dimethoxyethaanFASTKD3GLUD1GLUD1 (gene)Glutamate Dehydrogenase 1Glutamate dehydrogenaseGlutamic acidHyperammonemiaHyperinsulinemic hypoglycemiaHyperinsulinism-hyperammonemia syndromeList of OMIM disorder codesList of causes of hypoglycemiaList of human protein-coding genes 2Protein:GLUD1Sirtuin 4Urea cycle
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Glutamate dehydrogenase 1
GLUD1 (glutamate dehydrogenase 1) is a mitochondrial matrix enzyme, one of the family of glutamate dehydrogenases that are ubiquitous in life, with a key role in nitrogen and glutamate (Glu) metabolism and energy homeostasis. This dehydrogenase is expressed at high levels in liver, brain, pancreas and kidney, but not in muscle. In the pancreatic cells, GLUD1 is thought to be involved in insulin secretion mechanisms. In nervous tissue, where glutamate is present in concentrations higher than in the other tissues, GLUD1 appears to function in both the synthesis and the catabolism of glutamate and perhaps in ammonia detoxification.
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GLUD1 (glutamate dehydrogenase ...... aps in ammonia detoxification.
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GLUD1 (glutamate dehydrogenase ...... aps in ammonia detoxification.
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Glutamate dehydrogenase 1
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