Gran Coclé is an archaeological culture area of the so-called Intermediate Area in pre-Columbian Central America. The area largely coincides with the modern-day Panamanian province of Coclé, and consisted of a number of identifiable native cultures. Archaeologists have loosely designated these cultures by pottery style. The poorly studied La Mula period ranged from 150 BC to AD 300. It was followed by the Tonosi period, from AD 300 to AD 550, and by the Cubita period, from AD 550 to AD 700. A unified Native American culture appears to have flourished in this area from approximately 1200 BC until the 16th century.