The H.C. Pitney Variety Store Building is a commercial building in downtown Tampico, Illinois, United States, constructed in 1900. The building is part of a two-story commercial block along Main Street. Between 1919 and 1920, H.C. Pitney operated the building as the H.C. Pitney Variety Store, and the second-floor apartment was occupied by the family of 40th U.S. President Ronald Reagan. It is listed as a contributing property to the Tampico Main Street Historic District, which was added to the U.S. National Register of Historic Places in 1982.